PGx Comprehensive (genetics) – Empire City Laboratories | Medical Lab Testing ANTIBODY PCR COVID-19 SARS

PGx Comprehensive

Variations in drug response are linked to differences in an individual's genetic makeup. Typically, people inherit two copies of each gene. Those with extra copies of the CYP2D6 gene produce an excess of the enzyme, causing them to metabolize drugs rapidly. For example, they convert codeine to its active form, morphine, so quickly that a standard dose can result in morphine toxicity. Conversely, some CYP2D6 variants, caused by a single DNA change, produce a non-functional enzyme. People with these variants process codeine very slowly, if at all, resulting in little or no pain relief.

Tect code:

P1533

Sample type:

Cheek Buccal Swab

Preparation:

You do not need to do anything special to prepare for the sample collection. Fasting is not required for this test.

Test type:

In person or via trained mobile phlebotomist

Biomarkers

Symptoms or conditions analyzed by this test

The results classify patients based on how efficiently they metabolize medications, determined by the number of inherited functional or variant alleles. CYP gene variability generally falls into four categories: ultra-rapid (UM), normal (extensive) (EM), intermediate (IM), and poor metabolizers (PM).

Ultra-rapid metabolizer (UM): increased enzymatic activity due to duplications or multiplications of the functional allele.
Extensive metabolizer (EM): normal enzymatic activity due to the presence of at least one functional allele.
Intermediate metabolizer (IM): Moderately-decreased enzymatic activity with either two decreased activity alleles or one decreased activity allele and one null allele.
Poor metabolizer (PM): lack of enzyme activity as a result of two null (non-functional) alleles.

Question 1