DQ2/DQ8 and HLA-DQ Risk Assessment for Celiac Disease Celiac Disease DNA Testing can assess the genetic risk for developing the condition. The prevalence of Celiac Disease is estimated at about 1:100 in Caucasians, and it occurs more often in females with a gender ratio of about two-to-one. Furthermore, gluten intolerance is more frequent in at-risk groups, such as first-degree relatives of patients as well as individuals with specific genetic syndromes (Down, Turner, Williams) or autoimmune diseases (type I diabetes, thyroiditis and multiple sclerosis).