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Apolipoprotein E

The ApoE genetic marker (Apolipoprotein E) is one gene responsible for interpreting the likelihood for an individual to develop Alzheimer's disease.
Genetic markers are DNA sequences that can connect inherited diseases to specific genes. In the brain, ApoE is a protein that plays a role in removing harmful plaques that accumulate around nerve cells. These plaques are characteristic of Alzheimer's Disease and are made up of damaged proteins known as amyloid-ß (Aß), which cluster together to form toxic deposits. There are three types of ApoE proteins: E2, E3, and E4. Each person inherits two of these proteins, one from each parent.

Tect code:

9113

Sample type:

Cheek Buccal Swab

Preparation:

You do not need to do anything special to prepare for the sample collection. Fasting is not required for this test.

Test type:

In person or via trained mobile phlebotomist

How it works

Consult with your Health Care Provider

Your Health Care Provider can place the order for the test

Complete sample collection

This test requires a simple cheek swab 

Get fast results online

Access your results online as soon as they are available.
View results

About the Test
  • Apoe E2
  • ApoE E3
  • ApoE E4
 

Each type possesses a different level of risk:

  • Individuals with the E2 allele have the lower risk of developing Alzheimer’s Disease, as this variant of the protein is the most effective at clearing Aß plaques.
  • People with the E3 allele do not have an elevated risk of developing Alzheimer’s Disease.
  • People with the E4 allele have a greatly increased risk of developing Alzheimer’s Disease because this version of the protein is less effective at clearing Aß plaques.

Apolipoprotein E Test especially suited for patients experiencing the following symptoms or conditions:

  • Family history of dementia
  • Symptoms of memory loss
  • Reduction in language and speech skills not related to other conditions
  • Pattern of decreasing intellectual ability
FAQs
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