The Cortisol, Total, Serum test helps evaluate conditions related to abnormal cortisol production. High cortisol levels may indicate Cushing’s syndrome, characterized by symptoms such as obesity, hypertension, and muscle weakness. Low cortisol levels can suggest Addison’s disease, with symptoms like fatigue, weight loss, and low blood pressure. The test provides insight into adrenal function and helps diagnose and monitor these endocrine disorders, as well as assess the body’s stress response. Abnormal cortisol levels can indicate conditions such as Cushing’s syndrome (high cortisol) or Addison’s disease (low cortisol). Symptoms may include fatigue, weight changes, mood swings, and changes in blood pressure. The test is used to diagnose and monitor these conditions and to evaluate overall adrenal function.